Prediction of Drug Distribution in Rat and Humans Using an Artificial Neural Networks Ensemble and a PBPK Model. Purpose. To develop a QSAR model, based on calculated molecular descriptors and an Artificial Neural Networks Ensemble ANNE, for the estimation of rat tissue to blood partition coefficients Kt b, as well as the assessment of the applicability domain of the model and its utility in predicting the drug distribution in humans. Methods. A total of 1. Kt b values 7. 5 train and 2. A correlation between simple molecular descriptors for lipophilicity, ionization, size and hydrogen bonding capacity and Kt b data was attempted by using an ANNE. Results. Similar statistics were observed between the train and validation group of data with correlations, between the observed values and the predicted average ANNE values, of 0. A degradation of the correlations was observed for predicted values with high uncertainty, as judged by the standard deviations of the ANNE outputs. This was further observed when using the ANNE Kt b values in a Physiologically based pharmacokinetic PBPK model for predicting the Human Volume of distribution of another 5. Conclusions. This model available as a MS Excel workbook in the Supporting material of this article may be a valuable tool for prediction and simulation in early drug development, allowing the in silico estimation of rat Kt b values for PBPK purposes and also indicating its applicability domain. SWZqzzDI8/hqdefault.jpg' alt='Build Neural Network Model With Ms Excel Pdf File' title='Build Neural Network Model With Ms Excel Pdf File' />BibMe Free Bibliography Citation Maker MLA, APA, Chicago, Harvard. I only remember one practical writing lesson from my three years as an English major Whenever you can, put the best bits at the end of the sentence. Put the next. To develop a QSAR model, based on calculated molecular descriptors and an Artificial Neural Networks Ensemble ANNE, for the estimation of rat tissuetoblood. Is artificial intelligence the same thing as machine learning And what is a neural network This slideshow explains fundamental AI terminology in everyday terms. MS Paint, the first app you used for editing images, will probably be killed off in future updates of Windows 10, replaced by the new app Paint 3D. Microsoft lists. KEY WORDSArtificial Neural Networks rat tissue to blood partition coefficients QSAR PBPK volume of distribution. Partner Perspectives. Partner Perspectives. Partner Perspectives. White Papers. Current Issue. Wadsworth Case Serial Numbers. Digital Transformation Myths Truths. Transformation is on every IT organizations to do list, but effectively transforming IT means a major shift in technology as well as business models and culture. In this IT Trend Report, we examine some of the misconceptions of digital transformation and look at steps you can take to succeed technically and culturally. Interop ITX 2. State Of Dev. Ops Report. The Dev. Ops movement brings application development and infrastructure operations together to increase efficiency and deploy applications more quickly. But embracing Dev. Ops means making significant cultural, organizational, and technological changes. This research report will examine how and why IT organizations are adopting Dev. Ops methodologies, the effects on their staff and processes, and the tools they are utilizing for the best results. Video. Sponsored Video. Slideshows. Twitter Feed.